Liverpool, Borussia Dortmund, Paris Saint-Germain and Porto all made it safely though to the Champions League quarter-finals and now Manchester City, Chelsea, Real Madrid and Bayern Munich are looking to join them from the Last 16.
Here's everything you need to know ahead of this week's second leg matches...
Manchester City vs Borussia Monchengladbach
Where: Puskas Arena, Budapest
When: Tuesday, March 16
Kick-off time: 8pm
TV: BT Sport
First leg score: 2-0
Manchester City have won four Premier League title since 2012 and look set to clinch a fifth, sitting 14 points clear of second placed Manchester United. Considered one of the greatest teams of the last decade, the Champions League has eluded them. Can they go on and lift the famous trophy, first dispatching Borussia Monchengladbach in the last 16?
The Germans were European powerhouses in the Seventies and are a strong outfit today though they arrive at the Etihad currently tenth in the Bundesliga table having lost their last six fixtures.
Sportsman Stat: Pep Guardiola’s first match in charge of Manchester City in the Champions League was a 4-0 win over Borussia Monchengladbach and since the start of the 2016-17 season, City have won more games (16) and scored more goals (59) than any English side in the competition
Betfred odds: Man City are 9/4 to win the Champions League this season.
Real Madrid vs Atalanta
Where: Estadio Alfredo Di Stefano, Madrid
When: Tuesday, March 16
Kick-off time: 8pm
TV: BT Sport
First leg score: 1-0
Real Madrid may be chasing city rivals Atletico at the top of the La Liga table but Zinedine Zidane’s men will still be fully focused as they look to win the Champions League a record 14 times. It’s just what they do.
However, Atalanta, only losing 1-0 from the first leg, will prove tricky opposition and are fourth in Serie A, three points behind Juventus and above Napoli, Roma and Lazio.
Sportsman Stat: Real Madrid have won 11 of their last 12 games against Italian opposition in the Champions League, scoring at least twice in ten of those matches.
Betfred odds: Real Madrid are 11/10 to win the second leg against Atalanta
Chelsea vs Atletico Madrid
Where: Stamford Bridge, London
When: Wednesday, March 17
Kick-off time: 8pm
TV: BT Sport
First leg score: 1-0
Chelsea scored a vital away goal against Atletico courtesy of a brilliant Olivier Giroud overhead kick in the first leg. With Thomas Tuchel at the Stamford Bridge helm, the Blues have conceded only two goals in 12 matches meaning Luis Suarez and Co will have to do something pretty special to find the net.
Diego Simeone’s side fired a blank at Getafe during domestic action on Saturday, even while the hosts played the final twenty minutes with ten men, and they will have to find their shooting boots if they are to progress to the quarter-finals.
Sportsman Stat: Atletico Madrid have lost three Champions League matches against Chelsea, which is their joint-most against an opponent along with city rivals Real Madrid and Bayern Munich.
Betfred odds: Atletico Madrid are 11/4 to qualify for the Champions League quarter-finals
Bayern Munich vs Lazio
Where: Allianz Arena, Munich
When: Wednesday, March 17
Kick-off time: 8pm
TV: BT Sport
First leg score: 4-1
Bayern Munich took a massive step into the last eight with a brilliant 4-1 win in Rome in the first leg. Jamal Musiala, who was born in Stuttgart but raised in England, netted in his first Champions League game to become the competition’s youngest English and German scorer.
For Lazio, they are likely playing for pride as needing four goals is a massively tall order against a stubborn Bayern reargaurd.
Sportsman Stat: Bayern host Lazio for the first time in European competition and none of the last 21 teams to have travelled to Bavaria for the first time in Europe have won since Bordeaux back in November 2009.
Betfred odds: Bayern Munich, who won the competition in 2020, are 10/3 to lift the trophy again this season
