High-flying Liverpool will play Championship Bristol City or League One Shrewsbury in the fourth round of the FA Cup.
The Reds’ main focus is on the Premier League title this season but, having got the better of rivals Everton with an understrength side, they will be heavy favourites to take another step closer to Wembley.
Manchester City, holders after thrashing Watford 6-0 in last season’s final, welcome Fulham to the Etihad Stadium.
Chelsea, winners of the competition three times in the last decade, go to Hull while Leicester will travel to Brentford.
Arsenal, having got the better of Leeds after a half-time rollicking from new boss Mikel Arteta, will play Bournemouth while Tottenham face a trip to Southampton should they beat Middlesbrough.
League One Tranmere will welcome Manchester United or Wolves to Merseyside if they can get the better of Watford in a replay after coming from three down to draw 3-3 at Vicarage Road.
Northampton Town, ninth in League Two and the lowest-ranked side already safely through, will take on England’s record goalscorer Wayne Rooney and his Derby side at Sixfields Stadium.
Carlisle, who earned a 2-2 draw at Cardiff while sat 21st in the fourth tier, will play Reading or Blackpool should they win their re-match against the Welsh side.
Intriguingly, it could be landlord vs tenant in the Midlands, as Birmingham could be the away side at their own St Andrew’s stadium, should Coventry, currently sharing the ground this season, beat Bristol Rovers in a replay.
All ties will be played between Friday, January 24 and Monday January 27.
FA Cup fourth round draw
Watford or Tranmere Rovers v Wolverhampton Wanderers or Manchester United
Hull City v Chelsea
Southampton v Middlesbrough or Tottenham Hotspur
Queens Park Rangers v Sheffield Wednesday
Bournemouth v Arsenal
Northampton Town v Derby County
Brentford v Leicester City
Millwall v Sheffield United
Reading or Blackpool v Cardiff City or Carlisle United
West Ham United v West Bromwich Albion
Burnley v Norwich City
Bristol Rovers or Coventry City v Birmingham City
Manchester City v Fulham
Rochdale or Newcastle United v Oxford United
Portsmouth v Barnsley
Bristol City or Shrewsbury Town v Liverpool