Ole Gunnar Solskjaer has confirmed that both Anthony Martial and Jesse Lingard will be out for between two and three weeks.
Speaking to reporters at his press conference on Friday, the Manchester United interim boss said the pair, who both sustained injuries in the 2-0 Champions League defeat, would have no chance of playing against Chelsea in the FA Cup or Liverpool in the Premier League.
Both have been in outstanding form for United since Solskjaer took over from the sacked Jose Mourinho and will force the Norwegian to make some major changes to his attacking line-up.
“I think they'll be out for two to three weeks," stated Solskjaer. "Then you're looking at younger players. Mason Greenwood, it's your time to step in, but he's injured, unfortunately, out for a couple of weeks as well.
"Sometimes that's how the luck goes, but Mason will get his chance. But it's a chance for anyone who plays – Alexis (Sanchez), Romelu (Lukaku), (Tahith) Chongy or Angel (Gomes).
“Anthony and Jesse have done really well for us, they're vital, but then again with Rom and Alexis, they've got different skill sets and will be able to show what they can do so need to gel a team together for Monday.”
Solskjaer said he was looking forward to the challenge of bouncing back after United suffered their first defeat since he took over.
“Great week,” said Solskajer. “You don't panic because you've lost a game, you don't change everything, it doesn't change the mindset at all. We need to keep working the way we do and play football the way we do.
"We want to go down to Chelsea, we want to have Liverpool here and impose ourselves on those games and there are quite a few other teams with injuries so you have to adapt to that.”