Harry Kane hobbled off the Wembley pitch in distress following Tottenham Hotspur's disappointing 1-0 loss at the hands of a galvanised Manchester United on Sunday and Mauricio Pochettino looked an anxious figure when asked about the England captain's injury.
"It was a bad tackle in the last moment. We will assess him," Pochettino told Sky Sports in the aftermath of a result that sees their quest for Premier League glory hit a significant bump in the road.
In the closing moments of the match Kane went in for a tackle with United defenders Victor Lindelof and Phil Jones, but dropped to the turf clutching his left ankle, and the Spurs striker looked genuinely hurt as United celebrated another victory under Ole Gunnar Solskjaer's stewardship.
As Spurs title journey derailed somewhat it could be a lot worse in the long run, as they are not only losing Son-Heung Min to the Asian Cup after today's game, they could potentially lose hotshot Kane and that will only leave Fernando Llorente as the only experienced striker in the squad.
Lucas Moura, Christian Eriksen and Dele Alli can play as attacking figures, but Kane's potential absence would leave a monstrous hole in the Spurs attack, and Pochettino must venture into the transfer market, if Kane is injured.
Spurs' bitter rivals Chelsea are in search of a striker and have been lining up a move for Gonzalo Higuain, who is currently on a season-long loan deal at AC Milan from Juventus, but with the Argentine striker open to a move to the Premier League then why don't Spurs dangle the carrot of a switch to north London.
It's an obvious longshot with Higuain keen to work with his old boss Maurizio Sarri again, but Pochettino has the lure of offering the 31-year-old Champions League football instead of the Blues offer of Europa League action, so the Spurs boss must make a quick move for a new striker should Kane's injury be bad and he's forced out of a crucial run of matches.
Harry Kane limps off after Tottenham's loss to Manchester United: