Chris Coleman is expected to join Sunderland as their new manager after he quit the Wales job tonight.
Wales failed to qualify for next year's World Cup but they enjoyed a tremendous run at the European Championships last year, reaching the semi-finals.
Coleman has been credited for getting the most out of a youthful Welsh team after he took over from Gary Speed.
In a statement tonight, the Welsh FA said: "Regretfully, Chris Coleman has resigned from his position as Wales National Team Manager with immediate effect.
"Chris was appointed manager in January 2012 in very difficult circumstances and has guided Wales to the semi-finals of EURO 2016, an incredible achievement that inspired a nation.
Jonathan Ford, Chief Executive of the Football Association of Wales, said: “We are extremely disappointed to see Chris’ tenure as Wales manager come to an end.
“The FAW and Wales as a nation will be eternally grateful for the job he has done over the last six years as National Team Manager, from travelling the length and breadth of Wales outside of the media spotlight to talk to players and supporters, to guiding us to the semi-finals of the European Championships.
“We wish Chris the very best of luck for the future as he returns to club management, a desire for which he has always been honest and open about.
"Kit Symons has also resigned from his position as National Team Coach and the FAW would like to put on record its gratitude for his commitment to the Wales National Team."
Sunderland have been without a manager since sacking Simon Grayson last month.