Manchester United's interim boss Ole Gunnar Solskjaer is facing one of his biggest tests since he replaced Jose Mourinho at Old Trafford.
The Reds were humbled 2-0 by Paris Saint-Germain in the Champions League on Tuesday and on Monday, they head for London to face Chelsea in the FA Cup fifth round.
Two players who were injured in the first half of that game - Jesse Lingard (hamstring) and Anthony Martial (groin) - will miss the game. Both have excelled since Solskjaer returned to United with Martial especially impressive in the new-look line-up.
Solskjaer was hoping to have both players back for the Premier League clash with Liverpool on February 25 but the suggestion is they will be out for between two and three weeks.
The changes are likely to see Marcus Rashford start along with two from Juan Mata, Romelu Lukaku and Alexis Sanchez.
Solskjaer was particularly damning when asked about Sanchez's performance, saying: "I can't do anything about Alexis Sanchez. When he plays he needs to find himself because we know there's a quality player there."
With so little faith being shown in Sanchez, could we finally see Brazilian international Fred given a rare chance to impress? He has barely featured since Solskjaer took over at Old Trafford but he could be ideal player to combat Chelsea's midfield play-maker Jorginho.
This will be the first time that Solskjaer has prepared his team after a defeat and while we do not foresee wholesale changes, the injuries to Martial and Lingard have provided him with the first big challenge of his managerial stint.
